Stock Trading Canary

United States · SEC Form 4 · Snapshot date: 2026-10-18 · Built: 2026-10-18 · 中文

← United States · Coverage record

US · SEC FORM 4

Spyre Therapeutics, Inc.

SYRE · Nasdaq · CIK 0001636282 · Healthcare · Biotechnology

INSIDER SIGNAL

No active buy signal

0 qualifying P purchase groups
in the current 180-day scoring window

94 Form 4 transaction lines observed in the same window
78 sales · 16 option, withholding, award, gift or other lines

Last qualifying purchase2022-08-25 · Souza Marcio · $50.4K

WHY NO ACTIVE SIGNAL?

Purchase activityNone
Recent buyingNone
Recent salesHigh
Buy signal statusInactive
Score anatomy

No score is calculated because there is no qualifying purchase in the active window. Unavailable inputs are not treated as zero or as a bearish signal.

ClusterNot calculated
Purchase sizeNot calculated
RoleNot calculated
RecencyNot calculated
ConvictionNot calculated

Why is there no score?

  • No qualifying open-market purchase supplies cluster, size, role, recency or conviction inputs.
  • Sales and other Form 4 activity remain visible as context and do not create a negative score.

Sales and other Form 4 activity are shown separately and do not create a negative buy signal. Absence of buying is not scored as bearish.

Insider activity timeline

Owner lanes show the latest 180 days. Symbol shape identifies the transaction type; sales remain context only.

AprMayJunJulAugSepOct
Burrows Scott LChief Financial Officer
○▼○▼○▼○▼○▼○▼▼○▼○▼
Sloan SheldonChief Medical Officer
○▼○▼○▼
Turtle CameronChief Executive Officer
▼▼▼▼▼▼
King-Jones HeidySee Remarks
○▼○▼○▼
Fairmount Funds Management LLC; Fairmount Healthcare Fund II L.P.; Harwin Peter Evan; Kiselak TomasDirector
○▼
HENDERSON MICHAEL THOMASDirector
▼▼
● Purchase▼ Sale○ Other

Showing the six most active owners; 1 additional owner(s) remain in Form 4 evidence.

Purchase breadth, concentration & cluster buying

These modules activate when qualifying purchases enter the 180-day research window.

SIGNAL HISTORY

No recorded active-signal snapshot

Scores are archived only when the company qualifies for a published US buy-signal snapshot. Last qualifying purchase: 2022-08-25 · Souza Marcio.

Recent Form 4 activity

0Purchases
96Sales
20Other Form 4 lines
32SEC filings · 365 days
BUYING0 qualifying P line(s) · 180 days
SELLING78 sale line(s) · context only
OTHER16 exercise / withholding / award / gift / other lines
10b5-1 / PLANNEDNot assessed

P is an open-market or private purchase. S is a sale. M, F, A and G usually describe exercises, tax withholding, awards and gifts. These categories remain visually separate.

Market context

Market context has not been captured for this ticker yet. The daily market-context job processes the US universe in rotating batches.

Short interest

Short interest is external context reported to FINRA by broker-dealers. It does not affect the Insider Signal.

Shares short
12,844,608
Previous report
12,129,443
Avg daily volume
1,444,056
Days to cover
8.9

FINRA settlement date: 2026-09-30 · Captured 2026-10-12 · FINRA equity short interest ↗. A share count, published about a week after each of two settlement dates a month; not a percentage of shares outstanding.

Historical equity purchases

Qualifying code P transactions in the local Form 4 history, including purchases outside the current signal window.

Transaction dateReporting ownerTypeSecuritySharesAvg. priceApprox. valueSource
2022-08-25Souza MarcioPurchase (P)Common Stock90,000USD 0.56USD 50,400SEC filing ↗
2022-06-08Hanley Jr. Michael ConickPurchase (P)Common Stock28,200USD 0.71USD 20,022SEC filing ↗
2022-03-16Quinn Anthony G.Purchase (P)Common Stock80,079USD 2.34USD 187,385SEC filing ↗
2022-03-15Quinn Anthony G.Purchase (P)Common Stock42,417USD 1.86USD 78,896SEC filing ↗
2022-03-14Quinn Anthony G.Purchase (P)Common Stock67,472USD 1.93USD 130,221SEC filing ↗
2022-03-11Quinn Anthony G.Purchase (P)Common Stock34,777USD 2.06USD 71,641SEC filing ↗
2022-03-11Alspaugh JonathanPurchase (P)Common Stock75,000USD 2.08USD 156,000SEC filing ↗
2021-12-13Shanafelt ArmenPurchase (P)Common Stock14,685USD 3.65USD 53,600SEC filing ↗
2021-12-10Shanafelt ArmenPurchase (P)Common Stock13,516USD 3.65USD 49,333SEC filing ↗
2021-12-10Quinn Anthony G.Purchase (P)Common Stock10,526USD 3.75USD 39,472SEC filing ↗
2021-12-09Shanafelt ArmenPurchase (P)Common Stock121,799USD 3.67USD 447,002SEC filing ↗
2021-12-09Quinn Anthony G.Purchase (P)Common Stock43,108USD 3.70USD 159,500SEC filing ↗
2021-12-09Alspaugh JonathanPurchase (P)Common Stock50,000USD 3.72USD 186,000SEC filing ↗
2021-08-18Alspaugh JonathanPurchase (P)Common Stock7,200USD 6.72USD 48,384SEC filing ↗
2021-08-17Alspaugh JonathanPurchase (P)Common Stock23,392USD 6.50USD 152,048SEC filing ↗

Form 4 evidence

116 transaction lines in the latest 365-day window; 149 in local history.

DateOwnerTypeSecuritySharesAvg. priceApprox. valueSource
2026-10-01Turtle CameronSale (S)Common Stock15,000USD 92.01USD 1,380,105SEC filing ↗
2026-10-01King-Jones HeidySale (S)Common Stock28,933USD 91.03USD 2,633,902SEC filing ↗
2026-10-01King-Jones HeidyOption exercise / conversion (M)Common Stock28,933USD 14.50USD 419,528SEC filing ↗
Show recent Form 4 evidence (30 grouped rows)
DateOwnerTypeSecuritySharesAvg. priceApprox. valueSource
2026-10-01Turtle CameronSale (S)Common Stock15,000USD 92.01USD 1,380,105SEC filing ↗
2026-10-01King-Jones HeidySale (S)Common Stock28,933USD 91.03USD 2,633,902SEC filing ↗
2026-10-01King-Jones HeidyOption exercise / conversion (M)Common Stock28,933USD 14.50USD 419,528SEC filing ↗
2026-10-01Burrows Scott LSale (S)Common Stock7,500USD 91.83USD 688,756SEC filing ↗
2026-10-01Burrows Scott LOption exercise / conversion (M)Common Stock7,500USD 14.50USD 108,750SEC filing ↗
2026-09-30Burrows Scott LSale (S)Common Stock17,500USD 89.89USD 1,573,075SEC filing ↗
2026-09-30Burrows Scott LOption exercise / conversion (M)Common Stock17,500USD 14.50USD 253,750SEC filing ↗
2026-09-02King-Jones HeidySale (S)Common Stock400USD 90.00USD 36,000SEC filing ↗
2026-09-02King-Jones HeidyOption exercise / conversion (M)Common Stock400USD 14.50USD 5,800SEC filing ↗
2026-09-02Burrows Scott LSale (S)Common Stock18,232USD 89.35USD 1,629,029SEC filing ↗
2026-09-01Turtle CameronSale (S)Common Stock15,000USD 87.29USD 1,309,410SEC filing ↗
2026-09-01King-Jones HeidySale (S)Common Stock27,999USD 87.31USD 2,444,529SEC filing ↗
2026-09-01King-Jones HeidyOption exercise / conversion (M)Common Stock27,999USD 14.50USD 405,986SEC filing ↗
2026-09-01Burrows Scott LSale (S)Common Stock7,500USD 87.31USD 654,792SEC filing ↗
2026-09-01Burrows Scott LOption exercise / conversion (M)Common Stock7,500USD 14.50USD 108,750SEC filing ↗
2026-08-07Albers Jeffrey W.Sale (S)Common Stock23,000USD 104.53USD 2,404,190SEC filing ↗
2026-08-07Albers Jeffrey W.Option exercise / conversion (M)Common Stock5,000USD 10.39USD 51,950SEC filing ↗
2026-08-03Turtle CameronSale (S)Common Stock15,000USD 95.51USD 1,432,705SEC filing ↗
2026-08-03Burrows Scott LSale (S)Common Stock7,500USD 95.57USD 716,771SEC filing ↗
2026-08-03Burrows Scott LOption exercise / conversion (M)Common Stock7,500USD 14.50USD 108,750SEC filing ↗
2026-07-01Turtle CameronSale (S)Common Stock15,000USD 87.69USD 1,315,346SEC filing ↗
2026-07-01Sloan SheldonSale (S)Common Stock8,334USD 87.70USD 730,896SEC filing ↗
2026-07-01Sloan SheldonOption exercise / conversion (M)Common Stock8,334USD 27.46USD 228,852SEC filing ↗
2026-07-01Burrows Scott LSale (S)Common Stock7,500USD 87.74USD 658,040SEC filing ↗
2026-07-01Burrows Scott LOption exercise / conversion (M)Common Stock7,500USD 14.50USD 108,750SEC filing ↗
2026-06-25Burrows Scott LSale (S)Common Stock15,000USD 87.13USD 1,307,000SEC filing ↗
2026-06-25Burrows Scott LOption exercise / conversion (M)Common Stock15,000USD 14.50USD 217,500SEC filing ↗
2026-06-23Fairmount Funds Management LLC; Fairmount Healthcare Fund II L.P.; Harwin Peter Evan; Kiselak TomasSale (S)Common Stock4,684,781USD 85.31USD 399,658,667SEC filing ↗
2026-06-23Fairmount Funds Management LLC; Fairmount Healthcare Fund II L.P.; Harwin Peter Evan; Kiselak TomasC (C)Common Stock666,680USD —USD —SEC filing ↗
2026-06-22HENDERSON MICHAEL THOMASSale (S)Common Stock20,000USD 100.00USD 2,000,000SEC filing ↗

Multiple price lines in one filing are grouped and share-weighted. Price and value are blank when a grouped filing line lacks price evidence.

Snapshot & identity

Snapshot date2026-10-18
Ranking versionUS-v1.2
Data qualityPASS ELIGIBLE · —
TickerSYRE
CIK0001636282
SectorHealthcare
IndustryBiotechnology Yahoo Finance
SEC SIC2834 Pharmaceutical Preparations
ExchangeNasdaq

Data coverage

Local Form 4 history149 transaction lines from 2020-04-30 to 2026-10-01
17 P purchase lines · 100 S sale lines · 32 other lines
SEC company submissionsOpen SEC filings ↗

Local ledger as of 2026-10-18. Mapping status is an audit field and does not erase SEC filing evidence.