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US INSIDER PROFILE · NON-SCORING RESEARCH
Opaleye Management Inc.
10% Owner
Identity: SEC owner CIK matched through an unambiguous cached owner-name crosswalk · Reporting-owner CIK: 0001595855
Purchase history
- Companies traded
- 6
- Purchases · 12M
- 55
- Purchases · 24M
- 80
- Average purchase
- $376.8K
- Median purchase
- $138.4K
- Gross purchase value
- $30.1M
Companies: Alpha Cognition Inc. | CODEXIS, INC. | Eton Pharmaceuticals, Inc. | Grace Therapeutics, Inc. | SANUWAVE Health, Inc. | Sol-Gel Technologies Ltd.
80 SEC accession(s) · 0 joint-owner event(s). Values are reported Form 4 transaction values in USD.
Qualifying purchase disclosures
| Published | Company | Ticker | Role | Reported value | SEC source |
|---|---|---|---|---|---|
| 2026-10-16 | Grace Therapeutics, Inc. | GRCE | 10% Owner | $136.2K | Open filing |
| 2026-10-13 | Grace Therapeutics, Inc. | GRCE | 10% Owner | $29.7K | Open filing |
| 2026-10-05 | Grace Therapeutics, Inc. | GRCE | 10% Owner | $123.8K | Open filing |
| 2026-10-02 | Alpha Cognition Inc. | ACOG | 10% Owner | $165.6K | Open filing |
| 2026-10-01 | Grace Therapeutics, Inc. | GRCE | 10% Owner | $16.4K | Open filing |
| 2026-09-28 | Alpha Cognition Inc. | ACOG | 10% Owner | $270.9K | Open filing |
| 2026-09-23 | Grace Therapeutics, Inc. | GRCE | 10% Owner | $31.7K | Open filing |
| 2026-09-16 | Alpha Cognition Inc. | ACOG | 10% Owner | $1.1M | Open filing |
| 2026-09-14 | Sol-Gel Technologies Ltd. | SLGL | 10% Owner | $207.4K | Open filing |
| 2026-09-10 | Grace Therapeutics, Inc. | GRCE | 10% Owner | $31.9K | Open filing |
| 2026-09-09 | Sol-Gel Technologies Ltd. | SLGL | 10% Owner | $687.2K | Open filing |
| 2026-09-03 | Sol-Gel Technologies Ltd. | SLGL | 10% Owner | $116.5K | Open filing |
| 2026-08-31 | Sol-Gel Technologies Ltd. | SLGL | 10% Owner | $2.8M | Open filing |
| 2026-08-19 | Grace Therapeutics, Inc. | GRCE | 10% Owner | $24.3K | Open filing |
| 2026-08-14 | Sol-Gel Technologies Ltd. | SLGL | 10% Owner | $68.0K | Open filing |
| 2026-08-04 | Alpha Cognition Inc. | ACOG | 10% Owner | $423.0K | Open filing |
| 2026-07-28 | Alpha Cognition Inc. | ACOG | 10% Owner | $1.0K | Open filing |
| 2026-07-24 | Alpha Cognition Inc. | ACOG | 10% Owner | $1.6M | Open filing |
| 2026-07-15 | Sol-Gel Technologies Ltd. | SLGL | 10% Owner | $124.8K | Open filing |
| 2026-07-10 | Sol-Gel Technologies Ltd. | SLGL | 10% Owner | $39.0K | Open filing |
Post-purchase outcomes
Excess return = stock return − S&P 500 ETF (SPY adjusted close) return. Returns start on the first shared trading session on or after publication.
| Period | Completed events | Price coverage | Hit rate | Median excess return | Average excess return | Worst excess return |
|---|---|---|---|---|---|---|
| 5D | 23Established | 29.5% (23/78) | 60.9% (14/23) | +2.0% | +2.9% | -8.8% |
| 20D | 20Established | 27.4% (20/73) | 80.0% (16/20) | +12.2% | +13.7% | -2.5% |
| 60D | 17Developing | 27.4% (17/62) | 52.9% (9/17) | +6.0% | +15.9% | -11.8% |
| 120D | 10Developing | 20.0% (10/50) | 100.0% (10/10) | +43.5% | +45.5% | +34.1% |
Research patterns
- First purchase in 12M
- 3/77
- Large purchase ≥ $100k
- 52/80
- Cluster buying · 15D
- 6/80
- Buying the dip
- 17/23
Routine / opportunistic: Not classifiable. These labels never affect the score or ranking.
Small samples remain visible but are not scored. This research enrichment never affects US-v1.1.